59P Prognostic impact of HPV status evaluation in head and neck squamous cell carcinomas

Worldwide, head and neck carcinomas represent the seventh most common cancer, with known risk factors such as alcohol consumption, use of various tobacco-based products, infection high-risk human papillomavirus (HR-HPV). Association HPV has already been proven to an indicator a better outcome for patients oropharyngeal squamous cell (SCC) only. This paper aimed highlight prognostic value status in all (SCC), independent location, evaluated using both immunohistochemical (IHC) molecular techniques, assess p16 marker (clone 16P04, JC2) predicting HPV. In this paper, 114 consecutive SCC cases were included. The association these was based on IHC expression PCR-based determination HR-HPV, according indications 8th edition American Joint Commission Cancer inconclusive or equivocal p16. There 20 females 94 males ages ranging from 32 86 years old. Most tumors negative (88.60%) there no statistically significant differences between age (p=0.5714), gender (p=0.6973), pT stage (p=0.5452). Kaplan-Meyer curves revealed difference overall survival (OS) positive versus (p=0.0472), independently their location. Although well-proved impact SCC, should be because it seems predictor, location stage. When is equivocal, established by determination.